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Synergistic effects of brain injury and aging: common mechanisms of proteostatic dysfunction.
Saikumar J, Bonini NM. Saikumar J, et al. Trends Neurosci. 2021 Sep;44(9):728-740. doi: 10.1016/j.tins.2021.06.003. Epub 2021 Jul 20. Trends Neurosci. 2021. PMID: 34301397 Free PMC article. Review.
Even after the symptoms of TBI are resolved, insidious molecular processes continue to develop, which often ultimately result in the development of age-associated neurodegenerative disorders. The precise molecular cascades that drive unhealthy brain aging are still largely …
Even after the symptoms of TBI are resolved, insidious molecular processes continue to develop, which often ultimately result in the develop …
DAMPs, ageing, and cancer: The 'DAMP Hypothesis'.
Huang J, Xie Y, Sun X, Zeh HJ 3rd, Kang R, Lotze MT, Tang D. Huang J, et al. Ageing Res Rev. 2015 Nov;24(Pt A):3-16. doi: 10.1016/j.arr.2014.10.004. Epub 2014 Oct 30. Ageing Res Rev. 2015. PMID: 25446804 Free PMC article. Review.
In particular, ageing and cancer share some common origins and hallmarks such as genomic instability, epigenetic alteration, aberrant telomeres, inflammation and immune injury, reprogrammed metabolism, and degradation system impairment (including within the ubiquitin …
In particular, ageing and cancer share some common origins and hallmarks such as genomic instability, epigenetic alteration, aberrant …
Walking the tightrope: proteostasis and neurodegenerative disease.
Yerbury JJ, Ooi L, Dillin A, Saunders DN, Hatters DM, Beart PM, Cashman NR, Wilson MR, Ecroyd H. Yerbury JJ, et al. J Neurochem. 2016 May;137(4):489-505. doi: 10.1111/jnc.13575. Epub 2016 Mar 8. J Neurochem. 2016. PMID: 26872075 Free article. Review.
Proteostasis is the maintenance of the proteome in the correct conformation, concentration, and location by functional pathways such as molecular chaperones and protein degradation machinery. Here, we discuss the potential roles of quality control pathways, both inside and …
Proteostasis is the maintenance of the proteome in the correct conformation, concentration, and location by functional pathways such as mole …
Proteome Stability as a Key Factor of Genome Integrity.
Gumeni S, Evangelakou Z, Gorgoulis VG, Trougakos IP. Gumeni S, et al. Int J Mol Sci. 2017 Sep 22;18(10):2036. doi: 10.3390/ijms18102036. Int J Mol Sci. 2017. PMID: 28937603 Free PMC article. Review.
Key components of the PN are the protein synthesis modules, the molecular chaperones and the two main degradation machineries, namely the autophagy-lysosome and the ubiquitin-proteasome pathways; also, part of the PN are a number of stress-responsive cellular …
Key components of the PN are the protein synthesis modules, the molecular chaperones and the two main degradation machineries, namely …
Natural compounds in the regulation of proteostatic pathways: An invincible artillery against stress, ageing, and diseases.
Upadhyay A. Upadhyay A. Acta Pharm Sin B. 2021 Oct;11(10):2995-3014. doi: 10.1016/j.apsb.2021.01.006. Epub 2021 Jan 7. Acta Pharm Sin B. 2021. PMID: 34729300 Free PMC article. Review.
These attributes are achieved by a highly coordinated protein quality control (PQC) system comprising chaperones to fold the proteins in a proper three-dimensional structure, ubiquitin-proteasome system for selective degradation of proteins, and autophagy for bulk c …
These attributes are achieved by a highly coordinated protein quality control (PQC) system comprising chaperones to fold the proteins in a p …
Changes of Protein Turnover in Aging Caenorhabditis elegans.
Dhondt I, Petyuk VA, Bauer S, Brewer HM, Smith RD, Depuydt G, Braeckman BP. Dhondt I, et al. Mol Cell Proteomics. 2017 Sep;16(9):1621-1633. doi: 10.1074/mcp.RA117.000049. Epub 2017 Jul 5. Mol Cell Proteomics. 2017. PMID: 28679685 Free PMC article.
Our data suggests increased heterogeneity of protein turnover of the translation machinery, whereas protein turnover of ubiquitin-proteasome and antioxidant systems are well-preserved over time. Hence, we presume that maintenance of quality control mechanisms …
Our data suggests increased heterogeneity of protein turnover of the translation machinery, whereas protein turnover of ubiquitin …
Role of molecular chaperones in neurodegenerative disorders.
Meriin AB, Sherman MY. Meriin AB, et al. Int J Hyperthermia. 2005 Aug;21(5):403-19. doi: 10.1080/02656730500041871. Int J Hyperthermia. 2005. PMID: 16048838 Free article. Review.
To handle a build-up of abnormal proteins cells employ a complicated machinery of molecular chaperones and various proteolytic systems. ...A very important consequence of a build-up and aggregation of misfolded proteins is impairment of the ubiquitin-proteasome …
To handle a build-up of abnormal proteins cells employ a complicated machinery of molecular chaperones and various proteolytic system …